高血压患者血尿酸与血脂水平的关系及临床意义

目的探讨高血压、高尿酸血症患者及高血压合并高尿酸血症患者血尿酸与血脂水平的关系。方法应用生化法检测103例高血压患者、39例利尿剂治疗后合并高尿酸血症的高血压患者、128例健康人及74例血压正常的高尿酸血症患者的血尿酸(UA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)浓度。结果高血压组、高尿酸血症组及高血压合并高尿酸血症组TC、TG、HDL-C、LDL-C升高发生率高于正常对照组,高血压和高尿酸血症对血脂水平均有影响。结论高血压患者血尿酸与血脂水平密切相关,高血压患者服用利尿剂引起高尿酸血症的同时可导致血脂异常。

The Relationship between Blood Uric Acid and Lipid in Hypertensive Patients

Objective To investigate the changes of the blood lipid level in patients with hypertension and in patients hyperuricemia or in patients with hypertension combined with hyperuricemia respectively. Methods Blood uric acid (UA), total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were measured in one hundred and three patients with hypertension, thirty nine patients with hypertension complicating with hyperuricemia caused by diuretic therapy, one hundred and twenty eight healthy subjects as control and seventy four patients with hyperuricemia and normal blood pressure. The volume of low density lipoprotein cholesterol (LDL-C)were calculated in all group. Results The incidence of increased serum lipid was higher in hyperuricemia group, hypertension group, hypertension combined with hyperuricemia group than in control group. Hypertension and hyperuricemia either had effects on serum lipid levels. Conclusion Hyperuricemia is correlated with hypercholesteremia closely. Hypertensive patients complicating with hyperuricemia caused by diuretic therapy could be coincident with disorder of blood lipid as well.