咪喹莫特对尖锐湿疣患者外周血白细胞介素-18表达的影响

目的研究咪喹莫特对尖锐湿疣患者外周血白细胞介素18(Interleukin 18,IL-18)表达的影响。方法利用荧光定量聚合酶链反应法测定22例尖锐湿疣患者治疗前后外周血及20例正常对照者外周血中IL-18 mRNA的定量表达。结果尖锐湿疣患者外周血中IL-18 mRNA的表达高于正常对照者外周血的表达水平(t=10.82,P<0.0001)。尖锐湿疣患者经过咪喹莫特治疗8周后,皮损消退,外周血中IL-18 mRNA的表达水平低于患者治疗前的表达水平(t=10.74,P<0.0001),但与正常对照者的表达水平无统计学差异(t=1.05,P>0.05)。结论咪喹莫特抑制尖锐湿疣外周血IL-18 mRNA的过度表达,这可能是咪喹莫特治疗尖锐湿疣的作用机制之一。

Regulation of imiquimod on interleukin 18 in the peripheral blood of patient with condyloma acuminatum

Objective To study the regulation of imiquimod on interleukin 18 （ IL-18 ） in the peripheral blood of patient with eondyloma acuminatum. Methods 22 adult patients with condyloma acuminatum and 20 healthy controls were sequential- ly enrolled in this study. Serum levels of IL-18mRNA were measured by real-time polymerase chain reaction in the 22 cases with condyloma acuminatum before and after treatment with imiquimod for 8 weeks and in the 20 healthy controls respectively. Results The serum level of IL-18mRNA before treatment was significantly higher than that of the healthy controls （ t = 10. 82 ,P 〈 0.0001 ）. Expression of serum IL-18mRNA in condyloma acuminatum was significantly decreased after 8 weeks＂ imi- quimod treatment （t = I0. 74,P 〈 0. 0001 ）. The serum level of IL-18mRNA was not significantly different between the post- treatment group and the control group （ t = 1.05,P 〉 0.05 ）. Conclusion Our data show that imiquimod could curb the over expression of IL-18mRNA in patients with condyloma acuminatum.