新疆地区维吾尔族和汉族人群血浆同型半胱氨酸水平与冠心病的关系

背景冠心病的主要独立危险因素包括性别、吸烟、高血压、高脂血症、糖尿病和老年等,但仅约50%的冠心病患者存在这些传统的危险因素,确立冠心病其他危险因素的必要性显得越来越突出。目的研究新疆地区维吾尔族、汉族血浆同型半胱氨酸(homocysteine,Hcy)水平与冠心病的关系,探讨同型半胱氨酸在不同民族冠心病发病中的地位。设计以诊断为依据的病例对照研究。地点、对象和方法收集2001-10/2002-01新疆医科大学第一附属医院心内科住院并行冠状动脉造影术的110例患者,按冠状动脉造影结果分为冠状动脉狭窄组(n=74)与冠状动脉正常组(n=36),并用高效液相色谱法测定血浆同型半胱氨酸水平。结果冠状动脉狭窄组血浆Hcy水平(μmol/L)明显高于冠状动脉正常组(17.40±10.95和11.78±4.56;t=3.79,P<0.05),冠状动脉狭窄组中高Hcy血症占41%,高于冠状动脉正常组(14%),差异有显著性意义(χ2=6.75,P<0.01)。冠状动脉狭窄组汉族血浆Hcy水平(μmol/L)显著高于冠状动脉正常组汉族(18.40±11.86和12.36±5.17;q=3.65,P<0.05),冠状动脉狭窄组和冠状动脉正常组维吾尔族之间差异无显著性意义(q=1.34,P>0.05)。结论新疆地区冠心病患者血浆同型半胱氨酸水平明显升高,高同型半胱氨酸血症所占比例较大,而同型半胱氨酸对新疆地区冠心病患

Relationship betweenplasm homocysteine level and coronary heart disease in Uigur and Han nationalitypopulations of Sinkiang Uighur Autonomous Region

BACKGROUND: The main independent risk factors of coronary heart disease (CHD) include sex, smoking, hypertension, hyperlipemia, diabetes and aging,etc.,which exist in only about 50% of the patients with CHD[1]. Therefore, it is much more necessary to determine other risk factors for CHD.OBJECTIVE: To investigate the correlation between plasma honocysteine (Hcy) level and CHD in Uigur and Han nationality populations of Sinkiang Uighur Autonomous Region and explore the role of Hcy in the pathogenesis of CHD in different Nationalities.DESIGN: Case-controlled study based on diagnosis.SETTING, PARTICIPANTS and METHODS: A total of 110 inpatientswho had received coronary arteriography in the Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University between October 2001 and January 2002 were selected in this study, and divided into coronary artery stenosis(CAS) group(n=74) and coronary artery normal(CAN)group( n = 36) based on the results of coronary arteriography. High performance liquid chromatograpy (HPLC) was used to assess the level of plasma Hcy in the patients.RESULTS: The level of plasma Hcy(μmol/L) in the CAS group(17.40 ±10.95 μmol/L) was significantly higher than that in the CAN group (11.78 ± 4.56 μmol/L, t = 3.79, P ＜ 0. 05). In the CAS group, 41% of the patients were found to have hyperhomocysteinemia, whose incidence was significantly higher than that in the CAN group(14% ) (X2 =6.75, P ＜ 0. 01);Plasma Hcy level of Han patients in CAS group(18.40 ± 11.86 μmol/L) was significantly higher than that in the CAN group(12.36±5.17 μmol/L, q=3.65, P ＜ 0.05) whereas no difference of the level was observed between Uigur patients of the CAS and CAN groups( q = 1.34, P＞ 0.05).CONCLUSION:There is a significant increase in the plasma Hcy level in the population with CHD in Sinkiang Uighur Autonomous Region, in which the incidence of hyperhomocysteinemia is much higher than that in the population without CHD. The effect of homocysteine is more obvious in Han patients.