肝素结合表皮生长因子样生长因子在银屑病早期皮损中的意义

目的：探讨肝素结合表皮生长因子样生长因子（HB－EGF）在银屑病发上期中的作用机制。方法：用原位杂交和免疫组化的方法检测正常组织、进行期银屑病皮损及其未受累皮肤中HB－EGF mRNA的蛋白表达。结果：在正常人皮肤组织中，HB－EGF mRNA和蛋白位于基底层（100％），基底上层仅有少量表达（16．67％）；在未受累表皮和银屑病皮损的周围部分中，HB－EGF的表达不仅位于基底层，且以灶状高表达于基底上层（分别为88．00％、80．00％）；在银屑病皮损的中央部分，基底上层无HB－EGF表达，基底层几乎不表达（4．00％）。结论：HB－EGF可能在银屑病发病的早期阶段起重要作用。

Significance of Heparin Binding Epidermal Growth Factor-like Growth Factor in Early Psoriatic Lesions

Objective To investigate the role of heparin binding epidermal growth factor-like growth factor(HB-EGF)in active psoriasis vulgaris.Methods HB-EGF mRNA and protein were detected by hy-bridization in situ and immunohistochemistry in normal skin tissues,lesional and non-lesional psoriatic skin of progressive stage.Results In normal skin tissues,the stain of HB-EGF mRNA and protein was located in the basal layer of epidermis(100.00%)and there was only a little expression in the suprabasal layers(16.67%).Focal overexpression was found in the suprabasal layers of non-lesional and peri-lesional psoriat-ic skin(88.00%,80.00%respectively);however,there was no HB-EGF mRNA protein expression in the superabasal layers of the central part of psoriatic lesions(0),and nearly no expression in the basal layer(4.00%).Conclusion HB-EGF may play an important role in the pathogenesis of early psoriasis.