移植物抗宿主病和移植物抗白血病的调控机制

通过深入认识移植物抗宿主病及移植物抗白血病效应中的病理生理，尤其是免疫细胞及相关细胞因子在其中的作用，找到减轻移植物抗宿主病，保留或增强移植物抗白血病效应的多种途径。移植物抗宿主病和移植物抗白血病效应的病理生理机制中，有着众多的细胞因子参与其间，不同的细胞因子对两者有着不同的影响，免疫细胞对两者也发挥重要的调控作用，通过研究发现某些细胞因子、特定的免疫细胞可发挥减轻移植物抗宿主病的同时可以保留或增强移植物抗白血病效应，实现移植物抗宿主病和移植物抗白血病效应的分离。深入了解细胞因子和免疫细胞在移植物抗宿主病及移植物抗白血病中的机制，可以多途径减轻移植物抗宿主病同时保留或增强移植物抗白血病效应。

Regulating effect of graft-versus-host-disease and graft-versus-leukemia

Through thorough understanding of the pathophysiology of graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effect, especial the effects of immune cells and cytokines, the article is designed to find out multiple ways to reduce GVHD and reserve or enhance GVL effect. Many kinds of cytokines are involved in the pathophysiologic mechanisms of GVHD and GVL effect. Different cytokines have different effects on GVHD and GVL effect. Immune cells play important roles in regulating GVHD and GVL effect. Studies shows that some cytokines and specific immune cells are able to reduce GVHD, as well as reserve or enhance GVL effect at the same time, which make the separation of GVL from GVHD can be achieved. On the whole, through thorough understanding of the mechanism of immune cells and cytokines in GVHD and GVL effect, we can find out multiple ways to reduce GVHD, as well as reserve or enhance GVL effect.