| 西南地区原发性肝癌抗癌基因P53点突变的研究 |
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| 引用本文： | 肖文华 刘为纹. 西南地区原发性肝癌抗癌基因P53点突变的研究[J]. 肿瘤防治研究, 1997, 24(3): 146-148 |
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| 作者姓名： | 肖文华 刘为纹 |
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| 作者单位： | 第三军医大学第一附属医院, 重庆 630038 |
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| 摘 要： | 本文采用PCR－RFLP技术对西南地区原发性肝细胞癌P53基因第248和249位密码子点突变进行了研究。约17．4%的肝癌存在第249位密码子点突变。没有发现248位密码突变。本研究结果提示癌基因P53点突变在该地区肝癌发病中起有一定作用；西南地区肝癌的发生可能有AFB1的参与。
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| 关 键 词： | 原发性肝癌 P~(53)基因 聚合酶链反应 限制性片断长度多态性 |
Study of the Mutation of P~(53) Gene in Primary Hepatocellular Carcinoma in Southwest China |
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| Wen-Hua Xiao,et al. Study of the Mutation of P~(53) Gene in Primary Hepatocellular Carcinoma in Southwest China[J]. Cancer Research on Prevention and Treatment, 1997, 24(3): 146-148 |
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| Authors: | Wen-Hua Xiao et al |
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| Affiliation: | Lab. of Gastroenterology, First Affiliated Hospital, Third Military University, Chongqing 630038 |
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| Abstract: | Mutation of P53 gene at codon 249 and 248 were detected with PCR-RELP in primary hepastocellular carcinoma from Southwest China. The mutation of P53 gene at codon 249 were observed in 8 cases (8/46) with positive of HBV serumal marker.However, no mutations at codon 248 were founded in 25 cases. The result suggested that mutation at codon 249 plays an importment role in HCC and AFB1 may associate with a part of hepatocelluar carcinoma in Southwest China. |
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| Keywords: | P~(53) gene Hepatocellular Cacinoma PCR-RFLP HBV |
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