Inhibitory effect of alpha-mangostin on Candida biofilms |
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| Authors: | Ruchadaporn Kaomongkolgit Kusuma Jamdee |
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| Affiliation: | 1.Department of Oral Diagnosis, Faculty of Dentistry,Naresuan University,Phitsanulok,Thailand;2.Faculty of Dentistry, Dental Science Research Center,Naresuan University,Phitsanulok,Thailand |
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| Abstract: | The objective of this study was to determine the inhibitory effect of alpha-mangostin on Candida biofilms. Candida species including Candida albicans, Candida krusei, Candida tropicalis, and Candida glabrata were tested. Candida biofilms were formed in flat-bottomed 96-well microtiter plates. The metabolic activity of cells within biofilms was quantified using the XTT assay. The results demonstrated that alpha-mangostin showed a significant anti-biofilm effect on both developing biofilms and preformed biofilms of Candida species. It may be concluded that alpha-mangostin could be an anti-biofilm agent against Candida species. Further in vivo investigations are needed to uncover the therapeutic values of this medicinal plant. |
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