The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report |
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| Authors: | Mayu Morita Seiji Asoda Kazuyuki Tsunoda Tomoya Soma Taneaki Nakagawa Masayori Shirakawa Hirofumi Shoji Hisao Yagishita Takeji Nishikawa Hiromasa Kawana |
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| Affiliation: | 1.Division of Oral and Maxillofacial Surgery, Department of Dentistry and Oral Surgery, School of Medicine,Keio University,Tokyo,Japan;2.Department of Oral Surgery,Shizuoka City Shimizu Hospital,Shizuoka,Japan;3.Oral and Maxillofacial Surgery,Nippon Dental University Hospital,Tokyo,Japan;4.Division of Oral Diagnosis, Dental and Maxillofacial Radiology and Oral Pathology Diagnostic Services,Nippon Dental University Hospital,Tokyo,Japan;5.Samoncho Dermatological Clinic,Tokyo,Japan |
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| Abstract: | Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus. |
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