| 水蛭素抑制创伤性脑水肿实验研究 |
| |
| 引用本文： | 郭伟,陈洪,王莉莉,陈建良,陈东,吕文,杨地. 水蛭素抑制创伤性脑水肿实验研究[J]. 新乡医学院学报, 2005, 22(4): 300-301,304 |
| |
| 作者姓名： | 郭伟 陈洪 王莉莉 陈建良 陈东 吕文 杨地 |
| |
| 作者单位： | 1. 暨南大学第二临床医学院,深圳市人民医院神经外科
2. 深圳市人民医院ICU科,广东,深圳,518020 |
| |
| 基金项目： | 深圳市科技局立项项目(编号:200405087) |
| |
| 摘 要： | 目的探讨水蛭素对脑挫裂伤后脑水肿的防治作用。方法制备家兔脑挫裂伤模型,观察不同时间家兔脑挫裂伤灶和周围脑组织含水量,并通过家兔脑挫裂伤创面贴附水蛭素明胶海绵实验,研究水蛭素对脑水肿抑制程度的影响。结果对照组家兔脑挫裂伤后脑组织含水量随时间的推移而升高,实验组各时间点脑组织含水量明显低于对照组(P<0.05)。结论水蛭素可抑制脑挫裂伤后脑水肿的发生和发展,早期应用水蛭素可减轻脑水肿,降低并发症,提高疗效。
|
| 关 键 词： | 创伤性脑水肿 水蛭素 兔 |
| 文章编号： | 1004-7239(2005)04-0300-03 |
Experimental study of traumatic brain edema inhibited by hirudin |
| |
| GUO Wei,CHEN Hong,WANG Li-li,et al. Experimental study of traumatic brain edema inhibited by hirudin[J]. Journal of Xinxiang Medical College, 2005, 22(4): 300-301,304 |
| |
| Authors: | GUO Wei CHEN Hong WANG Li-li et al |
| |
| Affiliation: | GUO Wei1,CHEN Hong1,WANG Li-li2,et al |
| |
| Abstract: | Objective To investigate the effects of prophylaxis and treatment of hirudin on traumatic brain edema.Methods A stable and repeatable brain contusion and laceration injury rabbit model was prepared, the effects of hirudin on the inhibition of traumatic brain edema was studied; brain water in contusion and laceration brain tissue was observed at different time (at 3, 24, 48,72 hour and 7 day), and compared with hirudin gelatin sponge group.Results The brain water in rabbit contusion and laceration brain was elevated as time went on, but hirudin reduced brain edema(P<0.05).Conclusion Hirudin is able to inhibit the occurrence and development of traumatic brain edema;it can reduce complication and improve therapeutic effects if hirudin is used at the early stage. |
| |
| Keywords: | traumatic brain edema hirudin rabbit |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
