| Abstract: | The kinetics of beta 2-microglobulin was studied during chronic arteriovenous filtration of the blood (altogether 8 sessions with a mean duration of 54 hrs, the rate of filtration, 0.5 kg/hr, substitution volume 12.5 kg/day) or intermittent ultrafiltration (altogether 20 sessions with a mean duration of 5.64 hrs, the rate of filtration 10 kg/hr; substitution volume, 10 kg/hr) in 8 patients with acute renal failure (ARF) and 5 ones with chronic renal failure (CRF). The authors employed filters HF-55,77,88 manufactured by "Gambro" (a polyamide membrane) and filters D-30 production by "Amicon" (a polysulfone membrane). The substitution was performed in some of ARF patients after the dilution and in some of them pre- and postdilution substitution was combined. CRF patients were parenterally substituted with balanced solution. Heparine was injected in a dose of 10-15 units per hour. The initial blood levels of beta 2microglobulin in the patients under chronic procedure were 16.6 +/- 70.7 (39.2 +/- 9.35) mg/litre, final levels 9.3 +/- 73.3 (32.5 +/- 6.36) mg/litre. The elimination volume of beta 2-microglobulin and the filtration solution was 80.5 +/- 291.2 (162.7 +/- 20.2) mg/day, comprised 1/5 of the pool and was in proportion to the amount of the substituted fluid. In the patients with intermittent filtration the initial blood levels of beta 2-microglobulin were 15-30 (25.5 +/- 1.5) mg/litre while its final levels were 5.7 +/- 26.9 (15.1 +/- 1.2) mg/litre. The elimination volume of beta 2-microglobulin and the filtration solution was 66.6 +/- 372.1 (176.1 +/- 15.8) mg per session. (ABSTRACT TRUNCATED AT 250 WORDS) |
