Isolation and characterization of a new Vesivirus from rabbits |
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| Authors: | Martín-Alonso José M Skilling Douglas E González-Molleda Lorenzo del Barrio Gloria Machín Angeles Keefer Nathan K Matson David O Iversen Patrick L Smith Alvin W Parra Francisco |
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| Institution: | Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Biotecnología de Asturias, Edificio Santiago Gascón, Campus El Cristo, Universidad de Oviedo, 33006 Oviedo, Spain. |
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| Abstract: | This report describes the isolation, cDNA cloning, complete genome nucleotide sequence, and partial characterization of a new cultivable calicivirus isolated from juvenile feeder European rabbits (Oryctolagus cuniculus) showing symptoms of diarrhea. Absence of neutralization by type-specific neutralizing antibodies for 40 caliciviruses and phylogenetic sequence comparisons of the open reading frame 1-encoded polyprotein with those of other caliciviruses demonstrate that this new calicivirus is a putative novel member of the Vesivirus genus which is closely related to the marine calicivirus subgroup. According to its putative classification, this new virus has been named rabbit vesivirus. |
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| Keywords: | Caliciviridae Vesivirus RNA genome |
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