Good intentions: risk factors for unintended pregnancies in the US cohort of a microbicide trial |
| |
| Authors: | Schreiber Courtney A Whittington Sara Cen Liyi Maslankowski Lisa |
| |
| Affiliation: | aUniversity of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA;bCenter for HIV Prevention Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA;cCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA;dCenter for HIV Prevention Research, University of Pennsylvania School of Medicine, Microbicides Trials Network, Philadelphia, PA 19104, USA |
| |
| Abstract: | BackgroundThe study was conducted to assess socio-behavioral and biological factors associated with unplanned pregnancy in the US cohort of a microbicide trial.Study DesignWe conducted a mixed-method, nested case-control study of risk factors for pregnancy within the US cohort of the microbicide trial HPTN 035. We developed an instrument to assess attitudes and beliefs about fertility control/contraceptive utilization among 122 women. Cases were HPTN 035 participants who became pregnant while enrolled, matched by time on study 1:4 with controls. Univariable and multivariable analysis were performed with pregnancy as the outcome of interest.ResultsContraceptive method change during the trial was associated with unplanned pregnancy (OR=1.76). Participant desire/partners' desire for future children (OR=4.95) and young age (OR=0.88 annually above age 19 years) were independently associated with unintended pregnancy.ConclusionWithin a trial that enrolls heterosexually active women, there may be ways to identify those at highest risk of becoming pregnant a priori. |
| |
| Keywords: | Contraception Microbicide Clinical trials Pregnancy |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
