Tract based spatial statistical analysis and voxel based morphometry of diffusion indices in temporal lobe epilepsy |
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| Authors: | Afzali Maryam Soltanian-Zadeh Hamid Elisevich Kost V |
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| Institution: | aControl and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, University of Tehran, Tehran 14395-515, Iran;bImage Analysis Laboratory, Henry Ford Hospital, Detroit, MI 48202, USA;cDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA |
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| Abstract: | White matter (WM) microstructure can be evaluated by diffusion tensor imaging (DTI). Tract-based spatial statistical (TBSS) analysis provides a means of assessing alterations in WM tracts. In this paper, both voxel-based morphometry (VBM) and TBSS are examined using DTI data of temporal lobe epilepsy (TLE) patients and nonepileptic subjects. In addition to fractional anisotropy (FA), ellipsoidal area ratio (EAR) is used in this study. Significant reductions of FA and EAR are identified by TBSS in the parahippocampal white matter. Because of methodological differences, TBSS detects more localized abnormalities than VBM, while the EAR is more sensitive to WM alteration than FA. |
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| Keywords: | Diffusion tensor magnetic resonance imaging Tract based spatial statistics Voxel based morphometry Fractional anisotropy Ellipsoidal area ratio Temporal lobe epilepsy |
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