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| 酒石酸托特罗定缓释片的研制 | |
| 引用本文： | 刘正和,张钧寿,曹德善. 酒石酸托特罗定缓释片的研制[J]. 中国生化药物杂志, 2004, 25(4): 230-232 |
| 作者姓名： | 刘正和 张钧寿 曹德善 |
| 作者单位： | 1. 南京美瑞制药有限公司,江苏,南京,210038 2. 中国药科大学,江苏,南京,210009 3. 南京先山科技有限公司,江苏,南京,210009 |
| 摘 要： | 目的研制酒石酸托特罗定缓释片。方法采用高效液相色谱法测定酒石酸托特罗定的含量 ,利用国内生产的缓控释辅料 ,以体外释放度为指标 ,优化处方工艺。结果所得缓释片体外释放实验表明 8h累积释放度>75 %。结论研制的酒石酸托特罗定缓释片的缓释效果好 ,工艺简单 ,可适合工业化生产。 |
| 关 键 词： | 酒石酸托特罗定 缓释片 含量测定 释放度 |
| 文章编号： | 1005-1678(2004)04-0230-03 |
| 修稿时间： | 2003-12-25 |
Studies on tolterodine tartrate sustained-release tablets |
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| LIU Zheng-he,ZHANG Jun-shou,CAO De-shan. Studies on tolterodine tartrate sustained-release tablets[J]. Chinese Journal of Biochemical Pharmaceutics, 2004, 25(4): 230-232 | |
| Authors: | LIU Zheng-he ZHANG Jun-shou CAO De-shan |
| Affiliation: | LIU Zheng-he1,ZHANG Jun-shou2,CAO De-shan3 |
| Abstract: | PurposeTo prepare tolterodine tartrate sustained-release tablets. MethodsOrthogonal project was employed to establish the relation between the match-ratio of HPMC to PVP and the releasing rate in vitro.ResultsThe accumulated released amount of tolterodine tartrate sustained-release tablets was more than 75% within 8 hours.ConclusionThe HPMC and PVP manufactured by domestic company can be used properly as barriers to prepare a matrix sustained-release tablet of tolterodine. The formulation and technique are feasible in industry. |
| Keywords: | tolterodine tartrate sustained-release tablet assay dissolution |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |