乳腺癌病人围手术期红细胞补受体Ⅰ活性及丙二醛水平的变化

目的 了解乳腺癌病人围手术期红细胞免疫状态及丙二醛（MDA）的变化。方法 30例病人随机分成静吸复合全麻（A组）和高位硬膜外阻滞（B）组，分别于麻醉前、麻醉后、手术中和术后1天、3天及5天取静脉血测定红细胞补体受体Ⅰ活性（CR－I）和MDA水平。结果 A组麻醉后、术中、术后1天及3天RBC－C3bRR、RBC－CaR及PEER均比麻醉前明显下降（P＜0．05或P＜0．01），B组仅在术中及术后1天明显下降（P＜0．05）。两组在各同一时点相比，A组麻醉后较B组低（P＜0．05）。RFIR和MDA在A组麻醉后、术中、术后1天及3天均明显高于麻醉前（P＜0．05或P＜0．01），B组也在术中及术后1天明显高于麻醉前（P＜0．05）。两组病人术后5天CR－Ⅰ和MDA均恢复到麻醉前水平。结论 乳腺癌病人围手术期红细胞免疫功能受到明显抑制，静吸复合全麻影响大于高位硬膜外阻滞，并且与红细胞免疫调节功能紊乱及血浆MDA水平有关。

Perioperative change of erythrocyte complement receptor I activity and malonydinldehyde content in patients undergoing radical recection of breast cancer

Objective To understand the change of erythrocyte immunity and matondialdehyde (MDA) in perioperative patients with mammary cancer. Methods 30 patients were divided randomly into two groups:group A(general anesthesia) and group B(epidural block). To estimate the activity of erythrocyte complement receptor I (CR- I ) and the lever of MDA, the venous blood were collected at the time points of before anesthesia, after anesthesia, during operation, and on the 1st, the 3rd, the 5th postoperative day. Resrlts Compared with before anesthesia, the RBCC3bRR, RBCCaR and RFER in group A were decreased statistically at the time points of after anesthesia, during operation, and on the 1st, the 3rd postoperative day(P ＜0.05 or P ＜0.01). Above mentioned index in group B were reduced significantly only during operation and on the 1st postoperative day. Between two groups, above mentioned index in group A were lower than those in group B(P＜0.05).Compared with before anesthesia, RFIR and MDA in group A were higher at the time points of after anesthesia, during operation, and on the 1st, the 3rd postoperative day(P＜0.05 or P＜0.01).but above mentioned index in group B rose only on the 1st postoperative day.CR- I and MDA in two groups restored to the lever of be fore anesthesia on the 5th postoperative day. Conclusion The perioperative immunological function of erythrocyte is obviously depressed by general anesthesia and epidural block, especially the former. This depression is relevant to the disorder of erythrocyte immunity regulating function and the lever of plasma MDA.