| 紫外光谱法测定混配农药的DNA加合作用 |
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| 引用本文： | 邵华,师以康. 紫外光谱法测定混配农药的DNA加合作用[J]. 中国公共卫生, 2003, 19(1): 81-82 |
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| 作者姓名： | 邵华 师以康 |
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| 作者单位： | 山东省劳动卫生职业病防治研究所,济南,250062 |
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| 摘 要： | 目的 研究混配农药的DNA加合作用。方法 采用紫外光谱移动法研究农药的DNA加合作用。结果 农药马拉硫磷、呋喃丹、氯氰菊本及其两两混配农药均可引起小牛胸腺DNA紫外光谱的改变。结论 农药马拉硫磷、呋喃丹、氯氰菊酯及其两两混配 经进入机体后，有与DNA形成加 的，如果在细胞复制前所形成的DNA加合物没有被修复或者被错误修复的活，则有可能导致基因突变，从而产生化学损伤。
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| 关 键 词： | 紫外光谱法 农药 DNA加合物 化学损伤 毒理学 丝裂霉素C |
| 文章编号： | 1001-0580(2003)01-0081-02 |
Determination of adduct actions of mixed pesticides on DNA by ultraviolet spectral method |
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| SHAO Hua,SHI Yi kang.Shandong Institute of Labor Health and Occupational Disease. Determination of adduct actions of mixed pesticides on DNA by ultraviolet spectral method[J]. Chinese Journal of Public Health, 2003, 19(1): 81-82 |
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| Authors: | SHAO Hua SHI Yi kang.Shandong Institute of Labor Health Occupational Disease |
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| Abstract: | Objective To study the adduct actions of mixed pesticides on DNA.Methods To study the adduct reactions of pestiside on DNA by ultraviolet spectral analysis.Results The change of ultraviolet spectrum of DNA would be caused by single or mixed Malathion?Carbonfuran?Cypermethrin.Conclusion Single or mixed Malathion?Carbonfuran and Cypermethrin may adduct with DNA after they enter body.If these DNA adducts are not repaired or misrepaired before cell duplication,the gene mutation and chemical damage would happen. |
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| Keywords: | pesticide DNA adduct chemical damage |
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