首页 | 本学科首页   官方微博 | 高级检索  
     

四藤一仙汤熏洗预防奥沙利铂所致周围神经毒性的临床观察
引用本文:姜靖雯,陈学武,蔡红兵,王琳,符英金,罗荣城. 四藤一仙汤熏洗预防奥沙利铂所致周围神经毒性的临床观察[J]. 南京中医药大学学报, 2015, 31(5): 420-423
作者姓名:姜靖雯  陈学武  蔡红兵  王琳  符英金  罗荣城
作者单位:1.海南省中医院肿瘤科,海南 海口?570203
摘    要:目的?观察四藤一仙汤熏洗对奥沙利铂所致周围神经毒性的预防作用。方法?选择需要接受含奥沙利铂方案化疗的结直肠癌患者150例,随机分为2组,每组75例。预防治疗组在接受化疗同时采用四藤一仙汤熏洗手足,每次40?min,每日2次;对照组只接受化疗,2组患者均至少接受2个疗程化疗。化疗结束后1月评估其周围神经毒性发生及分级情况,评价其预防作用。结果?预防治疗组、对照组周围神经毒性发生率分别为18.7%和56.0%,差异显著(P<0.01);预防治疗组和对照组周围神经毒性分级的平均秩次分别是60.63和90.37,预防治疗组周围神经毒性的分级明显低于对照组,有统计学意义(P<0.05);在发生2级及以上周围神经毒性的患者中,预防治疗组和对照组患者奥沙利铂累积剂量分别是1?054.76±124.6,823.47±190.67,差异具有统计学意义(P<0.05);Logisitic回归分析发现,中药熏洗是周围神经毒性发生的保护因素。结论?四藤一仙汤熏洗可以降低奥沙利铂所致周围神经毒性发生率、减轻其发生的严重程度,提高患者耐受奥沙利铂化疗累积量,且是周围神经毒性发生的独立保护因素。 

关 键 词:四藤一仙汤   周围神经毒性   奥沙利铂   熏洗
收稿时间:2015-01-04
修稿时间:2015-04-20

Clinical Observation on Preventive Effect of Oxiliplatin Induced Peripheral Neuropathy by Fumigation of Siteng Yixian Decoction
JIANG Jing-wen,CHEN Xue-wu,CAI Hong-bing,WANG Lin,FU Ying-jin,LUO Rong-cheng. Clinical Observation on Preventive Effect of Oxiliplatin Induced Peripheral Neuropathy by Fumigation of Siteng Yixian Decoction[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2015, 31(5): 420-423
Authors:JIANG Jing-wen  CHEN Xue-wu  CAI Hong-bing  WANG Lin  FU Ying-jin  LUO Rong-cheng
Affiliation:1.Oncology Department, Hainan Provincial Hospital of TCM, Haikou, 570203, China2.TCM-Integrated Hospital of Southern Medical University, Guangzhou, 510000, China3.Internal Medicine-Oncology, Hainan Provincial People's Hospital, Haikou, 570311, China
Abstract:OBJECTIVE?To observe the preventive effect of oxaliplatin induced peripheral neuropathy treated by fumigation of Siteng Yixian decoction. METHODS?Totally 150 colorectal cancer patients from oncology department Of Hainan provincial hospital of TCM between January 2010 and December 2014 were enrolled in this study. And they were randomized into two groups, with 75 cases in each. The patients in the control group only received oxaliplatin based chemotherapy. While the patients in the treatment group were given the chemotherapy combined with fumigation of Siteng Yixian decoction. The fumigation lasted for forty minutes a time, twice a day. After the treatment of two cycles chemotherapy, the incidence rate and severity classification of peripheral neuropathy was analyzed one month later to evaluate the preventive effect. RESULTS?The difference of incidence rate of peripheral neuropathy was significant, with the rate being 18.7% in the treatment group and 56.0% in the control group(P<0.01). The severity classification was evidently higher in the control group(90.37) than those in the treatment group(60.63), and there exised a statistical significance(P<0.05). Among the patients who had second degree peripheral neuropathy or above, the oxaliplatin accumulative dose was (1?054.76±124.6) in the treatment group and (823.47±190.67) in the control group, and the difference was statistically significant(P<0.05). Logistic regression indicated that fumigation of Siteng Yixian decoction was the protective factor for the oxaliplatin-induced peripheral neuropathy. CONCLUSION?Fumigation of Siteng Yixian decoction can reduce the incidence rate, decline the severity classification of oxaliplatin-induced peripheral neuropathy and increase the oxaliplatin tolerance dose. It is the independent preventive factor for oxaliplatin-induced peripheral neuropathy. 
Keywords:Siteng Yixian decoction   peripheral neuropathy   oxaliplatin-induced   fumigation
本文献已被 CNKI 等数据库收录!
点击此处可从《南京中医药大学学报》浏览原始摘要信息
点击此处可从《南京中医药大学学报》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号