The effect of photodynamic therapy on normal skeletal muscle in an animal model |
| |
| Authors: | E. B. Chevretton M. C. Berenbaum R. Bonnett |
| |
| Affiliation: | (1) Department of Experimental Pathology, St Mary's Hospital Medical School, W2 1PG London, UK;(2) Department of Ear, Nose and Throat Surgery and the Surgical Unit, The Royal London Hospital, Whitechapel, E1 1BB London, UK;(3) Department of Oncology, University College and Middlesex School of Medicine, Middlesex Hospital, W1N BAA London, UK;(4) Department of Chemistry, Queen Mary College, E1 4NS London, UK |
| |
| Abstract: | Six sensitizers [haematoporphyrin derivative (HPD), Photofrin II, themeta-, ortho- andpara- isomers of the tetra(hydroxyphenyl)porphyrins (m-, o-, andp-THPP) and the potassium salt ofp-THPP (K-p-THPP)] were compared in their ability to sensitize mouse skeletal muscle and tumours. Muscle damage was measured as percentage weight increase due to oedema 4h after illumination and as percentage cross-sectional area necrosis at 48h. These results were compared with those that had previously been obtained for depth of necrosis in subcutaneous tumours. All the photosensitizers damaged both tumours and skeletal muscle. Acost (muscle damage) vsbenefit (subcutaneous tumour necrosis) analysis of the results showed thatm-THPP was the most tumour selective sensitizer of those studied. In the long-term, muscle healed by regeneration and some fibrosis with full return of function. |
| |
| Keywords: | Photodynamic therapy Striated muscle necrosis Tumour necrosis Morphometry |
| 本文献已被 SpringerLink 等数据库收录！ |
|
