生长抑素治疗重症急性胰腺炎的临床研究

目的观察生长抑素施他宁及其类似物善宁治疗重症急性胰腺炎(SAP)的治疗效果及评估其临床价值。方法按Ranson标准判断病情严重程度，将106例病情大致相近的SAP患者分成施他宁治疗组37例，善宁治疗组36例及对照组33例。对照组用一般常规治疗方法，治疗组在一般常规治疗方法治疗的基础上加用施他宁6mg／d或善宁0．6mg／d，维持治疗7～14d。观察3组血尿淀粉酶变化、平均腹痛持续时间、禁食天数、住院天数、并发症、手术率及住院费用等多项指标。结果施他宁和善宁治疗SAP均能显著降低血尿淀粉酶水平，控制腹痛，缩短禁食时间和住院天数，减少并发症和手术率，并且没有明显的增加住院费用。结论生长抑素施他宁和善宁对SAP有明显疗效，可以阻止病情进展和恶化，减少并发症，改善预后。

Clinical Reaserch of Somatostatin in Treatment of Patients with Severity Acute Pancreatitis

Objective To observe the therapeutic effect of 14 peptid somatostatin(stilamin)and 8 peptid somatostatin(octreotide) on patients with severity acute pancreatitis (SAP) and evaluate its clinical value. Methods 106 patients with SAP were selected and divided into stilamin treatment group,octreotide treatment group and controlled group,the severity of disease of which was almost equivalent according to ranson criteria. The conventional therapy was administerd to the controlled group,the patients of somatostatin treatment groups was treated with stilamin 6 mg/d or octreotide 0.6 mg/d, lasting 7~14 d.To observe these index of the three groups such as level of serum amylase and urine amylase,average abdominal pain duration ,fasting duration, hospitalization duration, occurrence of complications ,operation ratio and hospitalization expenses. Results The results showed that both stilamin and octreotide decreased significantly level of serum amylase and urine amylase compared with the controlled group, shortened the duration of abdominal pain and fasting,shortened the hospitalization duration,lowered occurrence of complications and operation ratio.While average hospitalization expenses did not increase significantly. Conclusion The results suggest that both stilamin and octreotide may have good curative effect in the treatment of patients with SAP,which can prevent the disease from developing and aggravating continuously and improve prognosis.