山羊角对流感病毒感染和对机体免疫功能影响的研究

作者等研究了中药山羊角有以下发现:1.无直接灭活病毒作用;2.预先用山羊角处理的人胚皮肤肌肉纤维母细胞,抵抗流感和副流感病毒的能力增强;3.山羊角和乳蛋白水解物可配成良好的细胞维持液;4.以1%山羊角水煎剂腹腔注射,再以流感FM鼠适应株进行攻击,死亡率降低,并对α干扰素的产生有诱生协同作用;5.对体外人血白细胞诱生α,γ型干扰素无协同作用;6.对KN细胞的活性有明显促进作用。

STUDIES ON THE EFFECT OF WATER EXTRACT OF SHEEP HORN POWDER ON THE VIRAL INFECTION AND IMMUNITY

Water extract of sheep horn, (Capva ni-saus) a traditional Chinese medicine, isclinically approved for treatment of viralinfection of the respiratory tract. Thisstudy revealed that water extract of sheephorn had the following characters: (ESH) 1) ESH had no effect on direct ina-ctivation of virus. 2) ESH-treated human embryonic fibro-blast cells in vitro showed a slightly hi-gher resistance to infection of influenzaand parainfluenza viruses. 3) 1% ESHmixed with 0. 25% lactalbu-rain hydrolysate was an optimal mainten-ance medium for human fetal fibroblastcells in vitro. It was slightly superior toEagle's medium. 4) In experimental mouse influenza, ESHinjection into Peritoneal cavity was effe-ctive prophylactically. The death rate ofprevention group (drug administration be-fore virus challenge) was slightly lowerthan that of the control and therapy group(drug administration after virus cha-llenge). Mouse serum interferon levelsin prevention group and therapy groupwere slightly higher than that of the con-trol group. 5) ESH had nos ynergistic effect on bo-th IFN production induced by human PBLwith NDN and IFN production induced byhuman PBL with PHA. 6) 1-3% ESH enhanced NK activity ofhuman PBL.