| 壮骨素促进骨折愈合的实验研究 |
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| 引用本文： | 夏志道,房世源,常超英,王来鸿,蒋位庄,魏兑民,吴非. 壮骨素促进骨折愈合的实验研究[J]. 中国骨伤, 1994, 7(1): 7-9 |
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| 作者姓名： | 夏志道 房世源 常超英 王来鸿 蒋位庄 魏兑民 吴非 |
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| 作者单位： | 中国中医研究院骨伤科研究所，湖北武汉同济医科大学附属协和医院骨科，浙江省中医药研究院，贵阳中医学院骨伤科研究所 |
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| 摘 要： | 壮骨素及当归、川芎嗪注射液联用，用于家兔桡骨标准骨折模型的治疗。通过体重观察、Ｘ片和骨痂切片组织形态计量学分析，结果显示：单纯使用＂壮骨素＂灌胃治疗组比空白对照组更高的Ｘ片评分（Ｐ＜０．００１）、更高的外骨痂及有效骨痂密度，细胞水平显示活跃的破骨细胞活动（０．０１＜Ｐ＜０．０５）。＂壮骨素＂与活血化瘀中药联用组早期良好地控制了骨折后动物体重的下降，与对照组相比有非常显著性意义（Ｐ＜０．０１）；同时亦显示更高的Ｘ片评分（ｐ＜０．００１）、矿化骨痂密度（０．０１＜Ｐ＜０．０５），破骨细胞活性吸收面（０．０１＜Ｐ＜０．０５）和破骨细胞指数（Ｐ＜０．０１），切片显示良好的骨痂改建。
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| 关 键 词： | 壮骨素，骨折愈合，家兔，实验研究 |
Experimental study on Zhuang Gu Su(ZGS) in promoting fracture healing |
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| Xia Zhi-dao,Fang Shi-yuan. Experimental study on Zhuang Gu Su(ZGS) in promoting fracture healing[J]. China journal of orthopaedics and traumatology, 1994, 7(1): 7-9 |
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| Authors: | Xia Zhi-dao Fang Shi-yuan |
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| Affiliation: | Institute of Orthopaedics and Traumatology, China Academy of Traditional Chinese Medicine, Beijing 100700;Institute of Orthopaedics and Traumatology, China Academy of Traditional Chinese Medicine, Beijing 100700;Institute of Orthopaedics and Traumatology, China Academy of Traditional Chinese Medicine, Beijing 100700;Institute of Orthopaedics and Traumatology, China Academy of Traditional Chinese Medicine, Beijing 100700 |
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| Abstract: | Standard fracture model was produced in Rabbits which were divided into three groups to stury the effects of ZGS(abstracted from Bombyx mori L) and ZGS combined with injections of Angelica sinesis and Lingusticum wallichii, traditional herbs for treating the fracture. Thuough observation of body weight changes, the X -ray films, and the histomorphormetric analysis of callus section,the results indicated that there were higher X-ray skating(P<0. 001), more external callus and effective callus density, more osteoclast activity(0. 01
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| Keywords: | Zhuang Gu Su fracture healing rabbit experimental study |
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