糖尿病患者的C反应蛋白与细胞外基质变化

目的观察 2型糖尿病( T2DM)患者 C反应蛋白( CRP)与细胞外基质( ECM)的变化,并探讨其对 DM慢性并发症的影响.方法测定 64例 2型 DM者和 30例健康对照组的 CRP、透明质酸( HA)、Ⅳ型胶原( CⅣ)、Ⅲ型前胶原( PCⅢ)水平,并根据有无慢性并发症存在,把 2型 DM者分成 A、B两组,对各组间进行比较分析.结果① DM组的 CRP、HA、CⅣ水平均较正常对照组有显著意义的升高( P<0.05).而有慢性并发症的 A组较无并发症的 B组 CRP、CⅣ水平有显著意义的升高( P<0.05);②在合并有慢性并发症的 A组中, CRP与 CⅣ水平有正相关( r=0.3714, P<0.05),而在未分组的 DM组中,二者无相关性.结论 CRP与糖尿病慢性并发症有关,而 ECM特别是功能相关蛋白如 CⅣ增加,可能是 CRP与慢性并发症之间的介导因素.

The change of C-reactive protein and extracellular matrix in diabetes mellitus patients

Objective To investigate the change of C-reactive protein(CRP)and extracellular matrix(ECM)level in type2diabetes mellitus patients. Methods The plasma levels of CRP,hyaluronic acid(HA),collagen IV(CIV)and procollagen III(PCIII)were measured in64type2DM patients and30normal control cases.The DMgroup was divided into A and B groups according to with or without chronic complications.The results were compared with each other. Results (1)The plasma levels of CRP,HA,CIV and PCIII in DM patients were significantly higher than those of control group(P<0.05).CRP and CIVlevels in group A were significantly higher than those of group B.(2)The CRP levels were positively correlated with CIV in group A,but in all DMpatients they did not manifest correlation. Conclusion CRP is correlated with diabetic chronic complications,but the increase of ECMespecial CIV maybe the link between them.