| 氨甲环酸在体外循环冠脉搭桥手术中应用效果的系统评价 |
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| 引用本文： | 连春微,李辉,李茜,刘斌.氨甲环酸在体外循环冠脉搭桥手术中应用效果的系统评价[J].中国循证医学杂志,2011,11(2):150-160. |
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| 作者姓名： | 连春微 李辉 李茜 刘斌 |
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| 作者单位： | 四川大学华西医院麻醉科,成都,610041 |
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| 摘 要： | 目的系统评价氨甲环酸在体外循环冠脉搭桥手术中应用的有效性和安全性。方法计算机检索Cochrane图书馆、MEDLINE、CNKI、VIP、CBM(均从建库至2010.12),收集所有氨甲环酸用于体外循环冠脉搭桥手术的随机对照试验(RCT)。使用Cochrane系统评价方法对纳入研究进行质量评价后,采用RevMan 5.0软件进行Meta分析。结果共纳入22个RCT,包括2 424例患者。Meta分析结果显示:①出血量:在减少术中出血量方面,氨甲环酸不优于安慰剂(P=0.18);在减少术后出血量方面,氨甲环酸优于安慰剂6 h:WMD=–218.66,95%CI(–362.84,–74.47),P=0.003;24 h:WMD=–213.50,95%CI(–339.78,–87.21),P=0.0009;术后总出血量:WMD=–314.11,95%CI(–396.24,–231.98),P<0.00001]、氨基乙酸6 h:WMD=–209.00,95%CI(–362.24,–55.76),P<0.00001;24 h:WMD=–361.00,95%CI(–666.56,–55.44),P=0.02]、急性等...
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| 关 键 词： | 氨甲环酸 冠脉搭桥术 体外循环 随机对照试验 系统评价 |
Tranexamic Acid for Coronary Artery Bypass Grafting with On-pump: A Systematic Review |
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| LIAN Chun-wei,LI Hui,LI Qian,LIU Bin.Tranexamic Acid for Coronary Artery Bypass Grafting with On-pump: A Systematic Review[J].Chinese Journal of Evidence-based Medicine,2011,11(2):150-160. |
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| Authors: | LIAN Chun-wei LI Hui LI Qian LIU Bin |
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| Institution: | LIAN Chun-wei,LI Hui,LI Qian,LIU Bin* Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu 610041,China |
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| Abstract: | Objective To assess the efficacy and safety of tranexamic acid in coronary artery bypass grafting(CABG) with on-pump.Methods Randomized controlled trials(RCTs) of CABG were searched in The Cochrane Library,MEDLINE,CNKI,VIP,CBM from the date of their establishment to December 2010.The quality of the included studies was evaluated,and meta-analyses were performed with The Cochrane Collaboration's RevMan 5.0 software.Results A total of 22 studies involving 2424 patients were included.The results of meta-analys... |
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| Keywords: | Tranexamic acid Coronary artery bypass grafting Cardiopulmonary bypass Randomized controlled trial Systematic review |
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