Exploring the effect of previous inactivated influenza vaccination on seasonal influenza vaccine effectiveness against medically attended influenza: Results of the European I‐MOVE multicentre test‐negative case‐control study, 2011/2012‐2016/2017 |
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| Authors: | Marta Valenciano Esther Kissling Amparo Larrauri Baltazar Nunes Daniela Pitigoi Joan O'Donnell Annicka Reuss Judit Krisztina Horváth Iwona Paradowska‐Stankiewicz Caterina Rizzo Alessandra Falchi Isabelle Daviaud Mia Brytting Adam Meijer Bernard Kaic Alin Gherasim Ausenda Machado Alina Ivanciuc Lisa Domegan Brunhilde Schweiger Annamária Ferenczi Monika Korczyńska Antonino Bella Ana‐Maria Vilcu Anne Mosnier Katherina Zakikhany Marit de Lange Sanja Kure?i? Filipovi?ovi? Kari Johansen Alain Moren I‐MOVE primary care multicentre case‐control team |
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| Institution: | 1. Epidemiology, Epiconcept, Paris, France;2. National Centre of Epidemiology, Institute of Health Carlos III, Madrid, Spain;3. Department of Epidemiology, Instituto Nacional de Saúde, Doctor Ricardo Jorge, Lisboa, Portugal;4. University of Medicine and Pharmacy Carol Davila, Bucharest, Romania;5. Cantacuzino Institute, National Institute of Research – Development for Microbiology and Immunology, Bucharest, Romania;6. Health Service Executive – Health Protection Surveillance Centre, Dublin, Ireland;7. Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany;8. Department of Disease Prevention and Surveillance, National Centre for Epidemiology, Budapest, Hungary;9. National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland;10. National Center for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy;11. Université de Corse‐Inserm, Corte, France;12. Open Rome, Réseau des GROG, Paris, France;13. The Public Health Agency of Sweden, Stockholm, Sweden;14. Centre for Infectious Disease Control, National Institute of Public Health and Environment (RIVM), Bilthoven, The Netherlands;15. Hrvatski zavod za javno zdravstvo, Zagreb, Croatia;16. Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), UPMC Univ Paris 06, INSERM, Sorbonne Universités, Paris, France;17. European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden |
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| Abstract: | Background Results of previous influenza vaccination effects on current season influenza vaccine effectiveness (VE) are inconsistent. Objectives To explore previous influenza vaccination effects on current season VE among population targeted for vaccination. Methods We used 2011/2012 to 2016/2017 I‐MOVE primary care multicentre test‐negative data. For each season, we compared current season adjusted VE (aVE) between individuals vaccinated and unvaccinated in previous season. Using unvaccinated in both seasons as a reference, we then compared aVE between vaccinated in both seasons, current only, and previous only. Results We included 941, 2645 and 959 influenza‐like illness patients positive for influenza A(H1N1)pdm09, A(H3N2) and B, respectively, and 5532 controls. In 2011/2012, 2014/2015 and 2016/2017, A(H3N2) aVE point estimates among those vaccinated in previous season were ?68%, ?21% and ?19%, respectively; among unvaccinated in previous season, these were 33%, 48% and 46%, respectively (aVE not computable for influenza A(H1N1)pdm09 and B). Compared to current season vaccination only, VE for both seasons' vaccination was (i) similar in two of four seasons for A(H3N2) (absolute difference ad] 6% and 8%); (ii) lower in three of four seasons for influenza A(H1N1)pdm09 (ad 18%, 26% and 29%), in two seasons for influenza A(H3N2) (ad 27% and 39%) and in two of three seasons for influenza B (ad 26% and 37%); (iii) higher in one season for influenza A(H1N1)pdm09 (ad 20%) and influenza B (ad 24%). Conclusions We did not identify any pattern of previous influenza vaccination effect. Prospective cohort studies documenting influenza infections, vaccinations and vaccine types are needed to understand previous influenza vaccinations' effects. |
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| Keywords: | case‐control study influenza influenza vaccine multicentre study vaccine effectiveness |
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