Primary histologic diagnosis using automated whole slide imaging: a validation study |
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| Authors: | John R Gilbertson Jonhan Ho Leslie Anthony Drazen M Jukic Yukako Yagi Anil V Parwani |
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| Institution: | (1) Center for Pathology Informatics, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA;(2) Center for Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213, USA;(3) Department of Pathology, University of Pittsburgh School of Medicine, UPMC Presbyterian/Shadyside, Pittsburgh, PA 15232, USA;(4) Department of Dermatology, University of Pittsburgh School of Medicine, UPMC Presbyterian/Shadyside, Pittsburgh, PA 15232, USA;(5) Benedum Center for Oncology Informatics, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA |
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| Abstract: | Background Only prototypes 5 years ago, high-speed, automated whole slide imaging (WSI) systems (also called digital slide systems, virtual
microscopes or wide field imagers) are becoming increasingly capable and robust. Modern devices can capture a slide in 5 minutes
at spatial sampling periods of less than 0.5 micron/pixel. The capacity to rapidly digitize large numbers of slides should
eventually have a profound, positive impact on pathology. It is important, however, that pathologists validate these systems
during development, not only to identify their limitations but to guide their evolution. |
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