Humoral immune response to MUC5AC in patients with colorectal polyps and colorectal carcinoma |
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| Authors: | Belma Kocer John McKolanis Atilla Soran |
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| Affiliation: | (1) Research Fellow, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;(2) Senior Research Associate Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA;(3) Professor of Surgery, Magee-Womens Hospital of UPMC, 300 Halket St, Suite 2601, Pittsburgh, PA 15213, USA |
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| Abstract: | Background MUC5AC is a secreted mucin aberrantly expressed by colorectal polyps and carcinoma. It has been hypothesized that aberrant expression of MUC5AC in colorectal carcinoma tissues increased the overall survival of patients with colorectal carcinoma. The present study investigates the incidence of naturally occurring MUC5AC antibodies in the sera of normal individuals, patients with colonic polyps and patients with advanced colorectal carcinoma. A second aim was to determine the relationship of MUC5AC antibody with the prognosis of colorectal carcinoma. |
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