肝硬化患者中血清总胆汁酸测定的临床意义

背景：胆汁酸在肝内合成和分泌，因此可以作为反映肝细胞损害的指标之一。目的：探讨肝硬化患者血清总胆汁酸（TBA）测定的临床意义。方法：收集42例肝硬化患者的肝功能资料，比较TBA与其他常规肝功能指标的敏感性差异。结果：肝硬化组的TBA显著高于健康对照组（P＜0．01），其水平为健康对照组的6．9倍，异常率为74％，显著高于丙氨酸转氨酶（ALT）、γ－谷氨酰转移酶（γ－GT）和碱性磷酸酶（ALP）（P＜0．01）。肝硬化失代偿期患者的TBA水平显著高于代偿期患者（P＜0．01）。结论：TBA是反映肝硬化患者肝细胞损害的敏感指标之一。

Diagnostic Value of Serum Total Bile Acid in Patients with Liver Cirrhosis

Background: Bile acid is synthesized and excreted in liver, therefore it can reflect the hepatocyte injury. Aims: To study the diagnostic value of serum total bile acid (TBA) in patients with liver cirrhosis. Methods: The concentration of TBA was detected in 42 cases of cirrhosis, and compared with other routine liver function tests. Results: The level of TBA in patients with liver cirrhosis was significantly higher than that of healthy group (P<0.01), the increasing ratio (6.9) and the abnormality rate (74%) were significantly higher than those of alanine aminotransferase (ALT), r-glutamyl trans-ferase (r-GT) and alkaline phosphatase (ALP) (P<0.01). There was significant difference of TBA between the patients with compensated and those with decompensated cirrhosis (P<0.01). Conclusions: TBA is a sensitive test to reflect hepatocyte injury in patients with liver cirrhosis.