1-(2-硝基苯基)哌嗪盐酸盐的合成

目的：比较2种合成路线，合成1-(2-硝基苯基)哌嗪盐酸盐。方法：1．以β，β′-二氯代二乙基胺为起始原料，在质子中和剂存在条件下，经与硝基苯胺环和而得。2．以邻．硝基氯苯为起始原料，在质子性溶剂中，与无水哌嗪进行亲核取代而得。结果：产物经红外光谱测定结构，与标准图谱对照，证实与目标化合物结构一致。结论：方法1在收率与质量上优于方法2。

Synthesis of 1- (2-Nitrophenyl) Piperrazine Hydrochloride

Objective:To synthesise the target compound 1 (2 Nitrophenyl)piperazine hydrochloride. Methods: Two kinds of approaches were used and compared.In one of them, bis 2 chloro ethy lamines was used as initial material,then cyclocondensed with o Nitroanisole;The other is o Nitrochloropheny condensation with anhydropiperazine to get the target compound.Results:The synthesised compound was identified with IR spectrogram and the result indicated it was consistent with the proposed structure. Conclusion:The first approach is superior to the second one in terms of the yield and quality of the product.