Ⅲa期非小细胞肺癌综合治疗的临床分析

目的 探讨非小细胞肺癌综合治疗的标准及疗效。方法 对1991年至1999年底手术切除的812例Ⅲa期非小细胞肺癌（NSCLC）的治疗结果进行分析。同时,将全组中326例综合治疗与486例单纯手术病例进行对比。结果 全组5年生存率16．4％,其中综合治疗组23．5％,单纯手术组10．2％。综合治疗组5年生存率中鳞癌占27．6％,腺癌23．4％;单纯手术组5年生存率中鳞癌占15．2％,腺癌9．9％。结果显示：综合治疗组生存率高于单纯手术组。结论 多学科综合治疗应成为中、晚期NSCLC的标准治疗方式．并且根据不同TNM、病理类型选择不同治疗组合。

Combined therapy for stage IIIa non-small cell lung cancer

OBJECTIVE: To evaluate the long-term outcome of combined therapy for stage IIIa non-small cell lung cancer (NSCLC). METHODS: Eight and twelve patients with stage IIIa NSCLC, 662 males and 150 females, aged 58.6 (24-79), underwent surgical resection, 326 of which received pre- and postoperative chemotherapy and/or radiotherapy, and 486 of which received surgery alone. The patients were classified according to the TNM staging, and the specimens of resected cancer were examined pathologically. The clinical data of these patients were analyzed. RESULTS: The overall 5-year survival rate was 16.4%. The 5-year survival rate of the combined therapy group was 23.5%, significantly higher than that of the surgical resection alone group (P < 0.01). The 5-year survival rate was 27.6% for the squamous cell carcinoma (SCC), and 23.5% for adenocarcinoma (AC) in the combined therapy group; and was 115.2% for SCC and 9.9% for AC in the surgical resection alone group (all P < 0.01). CONCLUSION: The curative effectiveness of combined therapy is significantly better than surgical resection alone for stage IIIa NSCLC. However, The combination should be based on the TNM staging and pathological type.