| γ-亚麻酸对人癌细胞蛋白质合成和脂质过氧化的影响 |
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| 引用本文： | 马润娣 西村实. γ-亚麻酸对人癌细胞蛋白质合成和脂质过氧化的影响[J]. 营养学报, 1992, 14(2): 139-144 |
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| 作者姓名： | 马润娣 西村实 |
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| 作者单位： | 陕西省中医药研究院生物化学研究室，ティォン株式会社研究所，京都府立医科大学生化学教室，京都府立医科大学生化学教室，京都府立医科大学生化学教室，陕西省中医药研究院生物化学研究室 西安 710003 京都府立医科大学生化学教室 京都 日本，东京 日本，京都 日本，京都 日本，京都 日本，西安 710003 |
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| 摘 要： | 本文报告γ-亚麻酸对体外培养人癌细胞生长、蛋白质合成和脂质过氧化的影响。结果表明,γ-亚麻酸抑制人癌细胞生长和20、30kD蛋白质合成,并增强培养人结肠癌细胞的脂质过氧化,α-生育酚则部分抵消γ-亚麻酸的作用。上述结果提示,γ-亚麻酸的抗肿瘤效果可能是由于其对蛋白质合成的抑制作用,而蛋白质合成的抑制则可能是由增强的脂质过氧化所致。
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| 关 键 词： | γ-亚麻酸 蛋白质合成 腊质过氧化 人癌细胞 |
INHIBITION OF 20, 30-KD PROTEIN SYNTHESIS AND ENHANCEMENT OF LIPID PEROXIDATION BY γ- LINOLENIC ACID IN HUMAN CANCER CELLS |
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| Ma Rundi,Minoru Nishimura,Atsuko Nishino Hoyoku Nishino,Akio Iwashima,Yu Lijian. INHIBITION OF 20, 30-KD PROTEIN SYNTHESIS AND ENHANCEMENT OF LIPID PEROXIDATION BY γ- LINOLENIC ACID IN HUMAN CANCER CELLS[J]. Acta Nutrimenta Sinica, 1992, 14(2): 139-144 |
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| Authors: | Ma Rundi Minoru Nishimura Atsuko Nishino Hoyoku Nishino Akio Iwashima Yu Lijian |
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| Affiliation: | Ma Rundi,Minoru Nishimura,Atsuko Nishino Hoyoku Nishino,Akio Iwashima,Yu Lijian Department of Biochemistry,Shaanxi Provincial Academy of Traditional Chinese Medicineand Pharmacology,Xi' an,710003Research Laboratory,Lion Corporation,Tokyo 132,JapanDepartment of Biochemistry,Kyoto Prefectural University of Medicine,Kyoto 602,Japan |
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| Abstract: | Effects of γ-linolenic acid on the growth, protein synthesis and lipid peroxidation of human cancer cells in culture were studied.The results showed that γ-linolenic acid inhibited the growth and 20, 30-kD protein synthesis of human cancer cells, and enhanced lipoperoxidation in cultured human colon carcinoma cells, and that the addition of α-tocopherol partially abolished the effects of γ-linolenic acid. It suggested that the anti-tumor effect of γ-linolenic acid may be due to the inhibition of protein synthesis, which may result from increased lipid peroxidation caused by γ-linolenic acid. |
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| Keywords: | γ-linolenic acid protein synthesis lipid perpxidation human cancer cells |
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