| 粉防己碱对大鼠膀胱平滑肌的药理作用 |
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| 引用本文： | 胡敏,姚伟星,夏国瑾,江明性.粉防己碱对大鼠膀胱平滑肌的药理作用[J].华中科技大学学报(医学版),1999,28(3):0. |
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| 作者姓名： | 胡敏 姚伟星 夏国瑾 江明性 |
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| 作者单位： | 同济医科大学基础医学院药理学教研室,武汉,430030 |
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| 摘 要： | 研究植物源性钙通道阻滞剂粉防己碱（Ｔｅｔ）对大鼠膀胱平滑肌的作用。结果发现，在整体实验中，Ｔｅｔ８ｍｇ／ｋｇ灌胃能在较少影响血压、心率的情况下，降低膀胱平滑肌的收缩力（Ｐ＜０．０１）。在离体实验中，Ｔｅｔ（１０、３０μｍｏｌ／Ｌ）能浓度依赖性地非竞争性抑制由ＫＣｌ引起的大鼠正常和肥厚膀胱平滑肌的收缩反应，ＰＤ２′值分别为４．３５和３．７９。在连续每ｄ灌胃Ｔｅｔ８ｍｇ／ｋｇ６周后，能减轻膀胱重量并改善形态学变化，且明显降低膀胱对外源性激动剂如ＫＣｌ的反应性（Ｐ＜０．０１）。提示Ｔｅｔ在治疗某些泌尿系统疾病如膀胱激惹综合征等有一定的应用前景
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| 关 键 词： | 粉防己碱 肥厚 膀胱 肌，平滑 大鼠 |
Pharmacological Effects of Tetrandrine on the Function of Rat Bladder |
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| Hu Min,\ Yao Weixing,\ Xia Guojin\ et al.Pharmacological Effects of Tetrandrine on the Function of Rat Bladder[J].Journal of Huazhong University of Science and Technology(Health Sciences),1999,28(3):0. |
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| Authors: | Hu Min \ Yao Weixing \ Xia Guojin\ |
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| Institution: | Hu Min,\ Yao Weixing,\ Xia Guojin\ et al Department of Pharmacology,School of Basic Medical Sciences,\=Tongji Medical University,Wuhan 430030 |
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| Abstract: | Tetrandrine (Tet) is a calcium channel blocker derived from plant In vivo, the contractile force of bladder smooth muscle was depressed by Tet at a dose of 8 mg/kg (P<001) meanwhile bloodpressure and heart rate were slightly affected In vitro, Tet (10,30 mol/L) could dosedependently and noncompetivively depress the contraction of normal and hypertrophic rat bladder caused by KCl, with the PD2 values being 435 and 379 respectively. At a dose of Tet 8 mg/kg for 6 weeks, Tet could reduce the bladder weight and the responsiveness of bladder to KCl significantly(P<001), and improve morphological changes of hypertrophic rat bladder It is suggested that Tet may be of value in the treatment of some urological system disorders such as irritable bladder syndrome |
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| Keywords: | tetrandrine \ hypertrophy \ bladder \ muscle smooth |
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