溴隐亭对大鼠实验性自身免疫性葡萄膜视网膜炎的影响

目的 观察泌乳素(prolactin, PRL)释放抑制剂——溴隐亭(bromo criptine, BRC)阻断PRL对大鼠实验性自身免疫性葡萄膜视网膜炎（experimental autoimmune uveoretinitis，EAU）的治疗效果。 方法 24只Wistar大鼠用牛视网膜可溶性抗原免疫后，随机数字表法随机分为治疗组和对照组。治疗组每日给予BRC葡萄糖溶液 5 mg/(kg·d)经口灌服，对照组每日葡萄糖溶液50 g/L经口灌服，观察2组EAU发病情况。免疫15 d后评价大鼠迟发型变态反应（delayed type hypersensitivity，DTH）；免疫23 d后眼球摘除，行组织学检查。 结果 治疗组EAU发病率和组织学炎症评分均低于对照组，其差异均有显著性的意义(P＜0.05,P＜0.001)；2组之间DTH比较差异无显著性的意义 (P＞0.05)。 结论 在整体水平上，BRC干预能够抑制大鼠EAU的发生和减轻EAU的病情。 （中华眼底病杂志，2003，19：34-37）

Effect of bromocriptine on rats with experimental autoimmune uveoretinitis

Objective To investigate the effect of bromocriptine on rats with experimental autoimmune uveoretinitis.Methods Tweenty-four Wistar rats were immunized by bovine soluble antigen and randomly divided into treatment and control group. The rats in treatment group took bromocriptine orally with the dosage of 5 mg/(kg·d), which could inhibit prolactin (PRL) deliverance, while the rats in control group took glucose solution orally with the dosage of 50 g/(L·d). The clinical changes of all the rats and the delayed type hypersensitivity (DTH) response were detected. The rats were anesthetized and killed after im munized for 21 days, and the eyes were removed and examined histologically.Results The occurrence of EAU and histology scores of rats in treatment group were lower than the controls (P＜0.05,P＜0.001). The DTH response of two groups had no statistic difference (P＞0.05). Conclusions Bromocriptine can generally inhibit PRL deliverance, and may also inhibit the occurrence of EAU in rats through neuroendocrine-immune regulating network. (Chin J Ocul Fundus Dis，2003，19：34-37)