| 吸烟对多形核白细胞的丙二醛含量及超氧化物歧化酶活性的影响 |
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| 引用本文： | 徐军,侯恕. 吸烟对多形核白细胞的丙二醛含量及超氧化物歧化酶活性的影响[J]. 中国病理生理杂志, 1992, 0(6) |
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| 作者姓名： | 徐军 侯恕 |
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| 作者单位： | 广州呼吸病研究所(徐军)，广州呼吸病研究所(侯恕) |
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| 摘 要： | 比较了非吸烟,吸烟,吸烟并慢阻肺者动脉血多形核白细胞的脂质过氧化产物—丙二醛(MDA)含量以及细胞和血清的抗氧化酶—超氧化物歧化酶(SOD)的活性。结果表明:吸烟和吸烟并慢阻肺者多形核白细胞的MDA以及SOD活性高于非吸烟者(P<0.01,P<0.05)。血清SOD则吸烟者低于不吸烟者(P<0.01)。MDA含量与SOD活性间的相关分析提示:吸烟者多形核白细胞的SOD处于相对不足,血清SOD绝对不足,练上所述:长期吸烟可使血中氧化和抗氧化失去平衡。
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| 关 键 词： | 嗜中性白细胞 超氧化物歧化酶类 丙二醛 |
Effects of cigarette smoking on oxidative metabolism of human polymorphonuclear leukocyte, and the activity of serum superoxide dismutase |
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| Xu Jun,Hou Shu Guangzhou Institute of Respiratory Disease,Guangzhou. Effects of cigarette smoking on oxidative metabolism of human polymorphonuclear leukocyte, and the activity of serum superoxide dismutase[J]. Chinese Journal of Pathophysiology, 1992, 0(6) |
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| Authors: | Xu Jun Hou Shu Guangzhou Institute of Respiratory Disease Guangzhou |
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| Abstract: | To investigate the possible role of oxygen free radical in the development of COPD related to cigarette smoking, we studied polymorphonuclcar leukocyte (PMN) oxidative metablism in asymptomatic smokers, smokers with COPD and the control. It was found that the content of PMN-MDA(PMN-malondialdehyde) and the activiy of SOD(superoxide dismutase) of asymptomatic smokers and smokers with COPD significant higher than that of the control. (P
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| Keywords: | Neutrophils Superoxide dismutase(SOD) Malondialdehyde (MDA) |
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