众生胶囊改剂型主要药效学研究

目的:研究众生丸由丸剂改为胶囊剂后的主要药效学变化.方法:以抗病原微生物、解热、抗炎为指标比较众生丸与众生胶囊的药效.结果:众生胶囊体外对呼吸道感染的常见病原菌、条件致病菌和常见病毒均有不同程度的拮抗作用,体内对金黄色葡萄球菌和流感病毒感染小鼠的死亡率均有明显保护作用;同时具有显著的解热、抗炎作用,且呈量效关系,两种剂型药效无明显差异.结论:众生丸由丸剂改为胶囊剂后保持了原来的药效.

The Main Pharmacology Study of Zhongsheng Capsule Dosage Form Changing

Objective; To study pharmacological action variety of ZhongSheng Pill dosage form changing from pill to capsule. Methods:Using anti-pathogenic microbe,antipyretic and antipyrotic effect as the pharmacological index, we compared the phar-macological action between Zhongsheng Pill formation and Capsule formation. Results:Zhongsheng Capsule had various degrees extrane-ous antagonistic actions against famihar and conditioned pathogenic bacteria and virus of respiratory tract. Furthermore it coud also re-duce the death ratio of mouse infected by staphylococcus aureus and influenza virus, remove fever and diminish inflammation. All these effects had the dose-effect relationship. There were no difference between pill fromation and cpasule formation. Conclusion:Zhongsheng Capsule retain the original pharmacological action of Zhongsheng Pill after dosage form changing.