Comparison of cytotoxicity of mercury-selenium and mercury compounds on cultured cells |
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| Authors: | Y Mochizuki T Kobayashi R Doi |
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| Affiliation: | Department of Public Health, Asahikawa Medical College, 4-5 Nishikagura, Asahikawa, Hokkaido 078-11 Japan |
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| Abstract: | In vitro effects of mercury-selenium (Hg-Se) compounds, as compared with their original mercury compounds, against growth and viability of HeLa cells were studied. A water-soluble, ethanol-insoluble black complex (GX) formed from HgCl2, Na2SeO3 and GSH was less toxic than HgCl2, but the cytotoxicity of bis(methylmercuric) selenide (BMS) seemed to be similar to that of methylmercury. This may be due to the instability of BMS; i.e., there is a possibility that BMS decomposed to methylmercury and selenium under our culture conditions. |
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| Keywords: | Mercury selenium HeLa cells BMS, bis(methylmercuric) selenide CS, calf serum DMSO, dimethylsulfoxide GSH, reduced glutathione Hg-Se, mercury-selenium IC50, 50% growth inhibition concentration MEM, Eagle's minimal essential medium |
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