白介素-18在慢性阻塞性肺疾病气道炎症中的作用

目的:探讨白介素-18(IL-18)在慢性阻塞性肺疾病(COPD)气道炎症中的作用。方法:收集62例COPD患者急性发作期、缓解期痰液及血液,采用双抗体夹心酶联免疫吸附法(ELISA)测定IL-18水平。结果:COPD组在急性发作期和稳定期血清IL-18水平与对照组比较,差异有统计学意义;COPD急性发作期痰IL-18水平与对照组和COPD稳定期比较,差异均有统计学意义;COPD组在急性发作期和稳定期血清IL-18水平与痰IL-18水平比较,差异有统计学意义;COPD急性期及稳定期血中IL-18水平与FEV1.0占预计值%、FEV1.0/FVC均呈负相关;COPD急性期痰中IL-18水平与FEV1.0占预计值%、FEV1.0/FVC均呈负相关。结论:COPD患者诱导痰及血清中IL-18的水平与气道炎症和气流受限有关。

IL-18 in Senile Chronic Obstructive Pulmonary Disease and Its Clinical Significance

Objective:To investigate the role of the process of airway inflammation of chronic obstructive pulmonary patients.Methods:The sputum and serum of 62 COPD were collected in the period of exacerbation and alleviation.The level of IL-18 were tested using ELISA.Results:The level of IL-18 in serum of COPD group were higher than that in the control group.The IL-18 level of sputum in AECOPD was higher than that in stable stage and the control group.The IL-18 level in serum was significantly higher than that sputum for COPD group.The level of IL-18 in serum of AECOPD was inversely correlated with FEV1.0%Pred、FEV1.0/FVCP.The level of IL-18 in serum of the stable stage was inversely correlated with FEV1.0%Pred、FEV1.0/FVC.The level of IL-18 in sputum of AECOPD was inversely correlated with FEV1.0% Pred,FEV1.0/FVC.Conclusion:IL-18 participates in the procedure of airway inflammation.Surveillence of dynamic of IL-18 can reflect the severity of airway inflammation.