| 预先静脉注射维生素C对兔脊髓缺血再灌注损伤的保护作用 |
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| 引用本文： | 李贵振,杨勇,刘朝旭,吴华.预先静脉注射维生素C对兔脊髓缺血再灌注损伤的保护作用[J].国外医学：物理医学与康复学分册,2009,4(4):238-240. |
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| 作者姓名： | 李贵振 杨勇 刘朝旭 吴华 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院骨科,武汉,430030 |
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| 摘 要： | 目的：探讨预先静脉注射维生素C注射液对免脊髓缺血再灌注损伤的作用，并为其临床应用提供依据。方法：30只成年雄性家兔随机分成假手术组（A组）、缺血对照组（B组）、维生素c组（c组）各10只。A组仅松套腹主动脉；B组阻断左肾动脉下腹主动脉40min后再灌注4d，建立脊髓缺血再灌注损伤模型；C组于阻断腹主动脉前15min一次性静脉注射维生素c注射液0．5g／kg，其余操作同B组。于缺血即刻，再灌注即刻、2h、4h、8h、16h测定血清丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性；于再灌注24h、48h和96h采用Tarlov评分评定后肢神经功能；于再灌注96h观察脊髓组织病理学改变。结果：缺血再灌注各时点，家兔血清MDA含量：A组〈C组〈B组；SOD活性：A组〉c组〉B组；B组和c组间差异有统计学意义（P％0．05）。于各评定时间点，A组家兔无瘫痪，B组10只均完全性瘫痪，C组仅3只完全性瘫痪，B组和C组间差异有统计学意义（P〈0．05）。于再灌注96h与B组比较，C组家兔脊髓前角正常神经细胞数较多，凋亡神经元较少（P〈0．05）。结论：预先静脉注射维生素C对免脊髓缺血再灌注损伤有较好的保护作用。
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| 关 键 词： | 脊髓 缺血 再灌注损伤 维生素c |
The Protective Effect of Vitamin-C Intravenous Infusion on Rabbits Subjected to Ischemia-reperfusion after Spinal Cord Injury |
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| LI Gui-zhen,YANG Yong,LIU Chao-xu,WU Hua.The Protective Effect of Vitamin-C Intravenous Infusion on Rabbits Subjected to Ischemia-reperfusion after Spinal Cord Injury[J].Neural Injury and Functional Reconstruction,2009,4(4):238-240. |
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| Authors: | LI Gui-zhen YANG Yong LIU Chao-xu WU Hua |
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| Institution: | LI Gui-zhen,YANG Yong,LIU Chao-xu,WU Hua.Department of Orthopaedics,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Objective:To investigate the protective effect of vitamin-C Intravenous infusion on rabbits subjected to ischemia-reperfusion(I-R) injury after spinal cord ischemia.Methods:Thirty rabbits were randomly divided into three groups,A(sham operated,no I-R injury),B(control group,only with I-R injury),and C(I-R injury plus vitamin-C intravenous infusion).Spinal cord ischemia was induced by clamping the abdominal aorta below the left renal artery for 40 minutes.The animals in group C have been injected with vitami... |
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| Keywords: | spinal cord ischemia reperfusion injury vitamin-C |
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