Breast cancer in a multi-ethnic Asian setting: results from the Singapore-Malaysia hospital-based breast cancer registry |
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Authors: | Pathy Nirmala Bhoo Yip Cheng Har Taib Nur Aishah Hartman Mikael Saxena Nakul Iau Philip Bulgiba Awang M Lee Soo Chin Lim Siew Eng Wong John E L Verkooijen Helena M;Singapore-Malaysia Breast Cancer Working Group |
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Institution: | Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. ovenjjay@gmail.com |
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Abstract: | Two hospital-based breast cancer databases (University Malaya Medical Center, Malaysia n = 1513] and National University Hospital, Singapore n = 2545]) were merged into a regional registry of breast cancer patients diagnosed between 1990 and 2007. A review of the data found 51% of patients diagnosed before the age of 50 years. and 72% percent of the women were Chinese followed by Malays (16%), Indians (8%), and other races (4%). Median tumor size at presentation was 26 mm and about 25% of patients presented with TNM stage III or IV disease. Most tumors were of ductal histology (87%). Fifty-seven percent of tumors were estrogen receptor positive and 40% were poorly differentiated. Of those patients who had surgery, 70% had mastectomy while 30% had breast conserving surgery. Overall, chemotherapy was administered to 56% of patients and hormonal treatment to 60%. Five-year overall survival was 82.5% in patients with TNM stage 0 to stage II cancer, and 30.2% in those with later stages. |
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