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Similarities of antisera to casein and epithelial membrane antigen |
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| Authors: | M. G. Ormerod G. Bussolati J. P. Sloane K. Steele P. Gugliotta |
| Affiliation: | (1) Institute of Cancer Research, Royal Cancer Hospital, Haddow Laboratories, Clifton Avenue, SM2 5PX Sutton, Surrey;(2) Department of Histopathology, Royal Marsden Hospital, The Haddow Laboratories, Clifton, Avenue, SM2 5PX Sutton, Survey, Great Britain;(3) Istitutio di Anatomia e Istologia Patologica, University of Turin, Vis Santena 7, Torino, Italy |
| Abstract: | Summary Antisera raised against human milk fat globule membranes and against the casein fraction of human milk have been compared. Using an immunohistochemical stain of tissue sections it has been shown that many of the antigenic determinants detected by the different antisera are identical. A radioimmunoassay for epithelial membrane antigen (EMA) showed that casein preparations are associated with small quantities of EMA. Antisera to casein frequently contained appreciable concentrations of antibodies to EMA and this accounts for the immunohistochemical staining of non-mammary tissues. |
| Keywords: | Immunohistochemistry Casein Epithelial membrane antigen |
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