注射用氨苄西林钠／氯唑西林钠与不同溶媒配伍稳定性的研究

目的：研究注射用氨苄西林钠／氯唑西林钠（氨氯青霉素钠）与5种常用输液在不同放置时间、不同温度下的配伍稳定性。方法：将注射用氨苄西林钠／氯唑西林钠用5种常用输液分别配成溶液，用高效液相色谱法测定各配伍液中氨苄西林钠、氯唑西林钠的含量。结果：样品与5％葡萄糖注射液和葡萄糖氯化钠注射液配伍时，随着放置时间和温度的升高，各组溶液中氨苄西林钠和氯唑西林钠的含量下降，其中以葡萄糖注射液中者最为显著。结论：氨氯青霉素钠在5％葡萄糖和葡萄糖氯化钠注射液中不稳定。

Study on compatible stability of ampicloxacillin sodium for injection in five infusions

Objective: To investigate the compatible stability of ampicoxacillin sodium for injection in five infusions in different time and different temperature conditions. Methods: Ampicloxacillin sodium was dissolved in five infusions. Ampicillin and cloxacillin in ampicloxacillin sodium for injection were determined by HPLC,and the color changes of all infusions were observed. Results: The ampicillin and eloxacillin contents in ampicloxacillin sodium for injection declined with time and temperature increased. The most distinct were 5% glucose injection. Concision: Ampicloxacillin sodium for injection wasn't stable in 5% glucose, gluscose and sodium chloride injection.