| Notch信号通路调控调节性T细胞作用机制的研究进展 |
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| 引用本文： | 张同韩,刘海潮,廖贵清. Notch信号通路调控调节性T细胞作用机制的研究进展[J]. 国际免疫学杂志, 2009, 32(3): 184-188. DOI: 10.3760/cma.j.issn.1673-4394.2009.03.006 |
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| 作者姓名： | 张同韩 刘海潮 廖贵清 |
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| 作者单位： | 中山大学光华口腔医学院附属口腔医院口腔颌面外科,广州,510055;中山大学光华口腔医学院附属口腔医院口腔颌面外科,广州,510055;中山大学光华口腔医学院附属口腔医院口腔颌面外科,广州,510055 |
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| 摘 要： | Notch信号通路是脊椎动物和非脊椎动物进化上高度保守的信号途径。Notch信号传导途径与免疫系统存在着密切的关系，参与T细胞功能的调控，包括T细胞的活化和增殖，细胞因子分泌和Th1或Th2分化，也参与调节性T细胞（Treg）的产生、扩增和功能发挥。Notch信号途径不仅参与了免疫系统的发育，同时在成熟的免疫细胞功能调节中也具有重要的作用。
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| 关 键 词： | Notch 信号传导 调节性T细胞 调控 |
The progress on merhanisms of Notch signaling pathway regulate Treg cell |
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| ZHANG Tong-han,LIU Hai-chao,LIAO Gui-qing. The progress on merhanisms of Notch signaling pathway regulate Treg cell[J]. International Journal of Immunology, 2009, 32(3): 184-188. DOI: 10.3760/cma.j.issn.1673-4394.2009.03.006 |
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| Authors: | ZHANG Tong-han LIU Hai-chao LIAO Gui-qing |
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| Affiliation: | .( Department. of Oral and MaxiUofacial Surgery, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China) |
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| Abstract: | The Notch signaling pathway is evolutionarily conserved in vertebrate and non-vertebrate.For the past few years,investigations indicated that Notch signaling pathway and immunologic system have an inti-mate relationship.It takes part in the regulation of T cell'function including activation and proliferation,ex-ternalization of cytokines and Th1/Th2 cell differentiation.It's also participates in Treg's generation.differ-entiation,amplification and function.The Notch signaling pathway is not only takes part in the development of immune system but also possesses an important role in the regulation of immunological cells's function. |
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| Keywords: | Notch |
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