Optical Coherence Tomography in Inflammatory Bowel Disease: Prospective Evaluation of 35 Patients |
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Authors: | P Consolo G Strangio C Luigiano G Giacobbe S Pallio L Familiari |
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Institution: | (1) Department of Medicine and Pharmacology, University Hospital, Messina, Italy;(2) Department of Medicine and Pharmacology-Endoscopy Unit, University Hospital, Via Consolare Valeria, 1, 98125 Messina, Italy |
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Abstract: | Purpose Optical coherence tomography is a technique using infrared light in tissues of the gastrointestinal tract and human colon
affected by inflammatory diseases. We evaluated whether there are specific patterns of optical coherence tomography for inflammatory
bowel disease and compared the technique performance to the histology.
Methods Optical coherence tomography was performed in 35 patients (18 men; 31 ulcerative colitis, 4 Crohn’s disease). The images were
obtained from affected and normal colon at endoscopy. Two biopsies of the sites visualized were taken. Two endoscopists scored
the images, and two pathologists, blind to the endoscopy and optical coherence tomography, performed the histologic evaluation.
Results Three optical coherence tomography patterns were identified: 1) mucosal backscattering alteration, 2) delimited dark areas,
and 3) layered colonic wall. Compared with the histology, mucosal backscattering alteration was the most effective in recognizing
the disease in patients (P = 0.007 in colon segments affected, and P < 0.001 in normal segments). The sensitivity and specificity have been 100 and 78 percent, respectively.
Conclusions The in vivo optical coherence tomography correctly detected inflammatory bowel disease features in affected and apparently normal colon,
and allowed to discriminate patterns for active ulcerative colitis and Crohn’s disease. |
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Keywords: | Inflammatory bowel disease Optical coherence tomography Imaging technique Endoscopy |
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