| SIIA-C2191-A和B,黄灰链霉菌产生的多环口山酮类新抗生素I.菌种分类,发酵,分离纯化和生物学活性(英文) |
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| 引用本文： | 赵子翰,李俊英,杨晓雁,褚以文.SIIA-C2191-A和B,黄灰链霉菌产生的多环口山酮类新抗生素I.菌种分类,发酵,分离纯化和生物学活性(英文)[J].中国抗生素杂志,2003(10). |
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| 作者姓名： | 赵子翰 李俊英 杨晓雁 褚以文 |
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| 作者单位： | 四川抗菌素工业研究所 成都610051
(赵子翰，李俊英，杨晓雁)，四川抗菌素工业研究所 成都610051(褚以文) |
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| 摘 要： | 在筛选具有生物活性的放线菌新代谢产物的过程中 ,从放线菌 SIIA-A0 2 191的发酵产物中发现了新的多环口山酮类抗生素 SIIA-C2 191A及其溴代类似物 SIIA-C2 191B。基于形态学、化学分类和 16Sr DNA等数据 ,将分离自渤海湾沙地土壤的产生菌鉴定为灰黄链霉菌。活性化合物采用减压快速层析法和制备型高效液相进行分离纯化。化合物 SIIA-C2 191A和 SIIA-C2 191B均对革兰氏阳性菌显示强抗菌活性 ,但对革兰氏阴性菌的抗菌活性较弱
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| 关 键 词： | SIIA-C2191A SIIA-C2191B 灰黄链霉菌 口山酮类抗生素 |
SIIA-C2191-A and B, novel polycyclic xanthone antibio tics produced by Streptomyces flavogriseus I. Taxonomy, fermentation, isola tion and biological activities |
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| Zhao Zi-han,Li Jun-ying,Yan g Xiao-yan and Chu Yi-wen.SIIA-C2191-A and B, novel polycyclic xanthone antibio tics produced by Streptomyces flavogriseus I. Taxonomy, fermentation, isola tion and biological activities[J].Chinese Journal of Antibiotics,2003(10). |
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| Authors: | Zhao Zi-han Li Jun-ying Yan g Xiao-yan and Chu Yi-wen |
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| Institution: | Zhao Zi-han,Li Jun-ying,Yan g Xiao-yan and Chu Yi-wen * |
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| Abstract: | During the course of our screening program f or novel bioactive metabolites from actinomycetes, a new polycyclic xanthone ant ibiotic SIIA-C2191A and its bromo analog SIIA-C2191B were isolated from the cu lture broth supplemented with 0 5% KBr of an actinomycete strain. The producing strain, SIIA-A02191, was isolated from a sandy soil sample collected in Bohai Bay, China, and identified as Streptomyces flavogriseus based on phenotypic and genotypic data. SIIA-C2191-A and B were purified by vacuum flash chromatog raphy and preparative HPLC. Both compounds show good activity against Gram-posi tive bacteria but poor activity against Gram-negative bacteria. |
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| Keywords: | SIIA-C2191A SIIA-C2191B Streptomyces flavogriseus Xanthone antibiotics |
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