alpha 2-Adrenergic receptors are associated with renal proximal tubules |
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| Authors: | W S Young M J Kuhar |
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| Affiliation: | Departments of Pharmacology and Experimental Therapeutics, and Psychiatry and the Behavioral Sciences, The Johns Hopkins University of School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, U.S.A. |
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| Abstract: | The location of alpha 2-adrenergic receptors has been investigated in the guinea pig kidney. We used an in vitro labeling autoradiographic technique to examine the distribution of specific [3H]clonidine binding sites with the light microscope. alpha 2-Adrenergic receptors appeared to be located predominantly on the proximal tubules. The implication of this finding for renal physiology is discussed. |
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| Keywords: | Guinea pig kidney Autoradiography |
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