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A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia |
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| Authors: | Ryo Takano Chairul A. Nidom Maki Kiso Yukiko Muramoto Shinya Yamada Kyoko Shinya Yuko Sakai-Tagawa Yoshihiro Kawaoka |
| Affiliation: | (1) Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Shirokanedai, Minato-ku Tokyo, 108-8639, Japan;(2) Faculty of Veterinary Medicine, Airlangga University, Surabaya, 60115, Indonesia;(3) Collaborating Research Center Emerging and Reemerging Infectious Diseases, Tropical Disease Centre, Airlangga University, Surabaya, 60115, Indonesia;(4) International Centre for Medical Research and Treatment, Graduate School of Medicine, Kobe University, Chuo-ku Hyogo, 650-0017, Japan;(5) International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku Tokyo, 108-8639, Japan;(6) Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA; |
| Abstract: | Highly pathogenic avian influenza H5N1 viruses are circulating in many countries. We recently discovered that these viruses have been transmitted to pigs on multiple occasions in Indonesia. To investigate whether avian H5N1 influenza viruses adapted to mammals through their introduction into pigs, we examined the growth of avian and swine isolates in cell culture and compared their pathogenicity in mice. We found that swine isolates were less virulent to mice than avian isolates, suggesting that the viruses became attenuated during their replication in pigs. Continuous surveillance of H5N1 viruses among pigs is clearly warranted. |
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