Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction |
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Authors: | Martin Graham Wilding Clemente Capobianco Nadia Montanaro Genc Kabili Loredana Di Matteo Enrico Fusco Brian Dale |
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Institution: | 1. Centro Fecondazione Assistita, Clinica Villa del Sole, Via Manzoni 15, 80122, Napoli, Italy 2. Studio Medico Percorso Donna, Via Miranda 8, 71100, Foggia, Italy 3. Studio Medico, Viale Marconi 77, 65100, Pescara, Italy 4. Klinika ‘EGIAN’, Rruga E Kavaje, Ish Parku i Autobuzeve, Tirana, Albania 5. Tirana Maternity Hospital, Boulevard “B.Curri”, Tirana, Albania 6. Facolta di Medicina e Chirurgia, II Università degli Studi di Napoli, Via Costantinopoli, 16, 80100, Napoli, Italy
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Abstract: | Objectives To compare embryo survival, pregnancy and implantation rates after cryopreservation of human cleavage-stage embryos with slow-rate cryopreservation or vitrification. Study design 262 patients, attending for assisted reproduction, were prepared for oocyte retrieval using standard controlled ovarian hyperstimulation protocols. Excess embryos were cryopreserved on day 3 either by vitrification, or slow-rate cryopreservation in a programmable freezer. Cycles of thawing were monitored for thaw efficiency, pregnancy and implantation rates. Results Clinical pregnancy and implantation rates were highly comparable between cycles in which day 3 embryos were thawed either after slow-rate cryopreservation or vitrification. Conclusions These data suggest that vitrification of human embryos during assisted reproduction cycles achieves comparable success rates to fresh cycles and therefore can be applied in the laboratory of assisted reproduction. |
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