LEC鼠自发性肝癌谷胱甘肽S-转移酶表达的意义

目的：观察LEC大鼠自发性肝癌谷胱甘肽S-转移酶(GST-P)的蛋白表达，探讨GST-P对原发性肝癌早期诊断的价值。方法：采用免疫组织化学方法检测LEC大鼠肝脏GST-P的表达。结果：67周龄LEC鼠即肝癌组GST-P的表达率（96.97%）明显高于4~6个月龄LEC鼠即肝炎组（37.5%）及SD大鼠组（9.38%）的表达率(P<0.01)，4~6个月龄LEC鼠GST-P的表达率高于SD大鼠组(P<0.05)。结论：GST-P可作为大鼠原发性肝癌早期诊断的肿瘤标志物。

Significance of GST-P expression in spontaneous hepatocellular carcinoma of LEC rats

Objective To observe the glutathione S-transferas P (GST-P) expression in spontaneous hepatocellular carcinoma of LEC rats,then discuss the value of GST-P in early diagnosis for spontaneous hepatocellular carcinoma.Methods The immunohistochemical method was used to detect the expression of GST-P in LEC rat liver.Results The GST-P expression of hepatocarcinoma group of LEC rats (67 weeks) was higher than that in hepatitis group of LEC rat (4-6 months) and SD rat group (positive rates were 96.97%,37.5%,9.38%, respectively),(P<0.01); the GST-P expression rate in hepatitis group of LEC rat (4-6 months) was higher than that in SD rat group(P<0.05).Conclusion GST-P can be regarded as the tumour marker to diagnose spontaneous hepatocellular carcinoma in early stage.