直肠癌术前动脉插管化疗后手术时机的选择

探讨直肠癌患者术前动脉管化疗后的手术时机。方法对２７例Ｄｕｋｅｓ’Ｂ－Ｃ期直肠癌患者,选择肠系膜下动脉或左髂内动脉,以５－氟脲嘧啶６００ｍｇ／ｍ＾２、丝裂霉素１５ｍｇ／ｍ＾２、表阿霉素３０ｍｇ／ｍ＾２、丝裂霉素１５ｍｇ／

Effects of inflammatory infiltration on the formation of abdominal aortic aneurysm

Objective To explore inflammatory infiltration and its effects on the formation of abdominal aortic aneurysm (AAA). Methods Immunohistochemical technique was used to detect lymphocyte(CD45 positive) and macrophage (CD68 positive) infiltration while in situ hybridization was applied to investigate the mRNA expression of Matrix Metalloprotainase 9 (MMP 9) in 20 cases of human AAA and 4 cases of normal human abdominal aortas. Results Inflammatory infiltration occurred in every case of AAA with various degree, and there was a parallel tendency between the degree of injury of abdominal aortic elastin and that of inflammatory infiltration in AAA. Inflammatory infiltration was not found in normal aortas. MMP 9 mRNA was detected in macrophages and lymphocytes in all 20 cases, in smooth muscle cells in 13, and not in normal abdominal aortas. Conclusions Inflammatory infiltration attended and enhanced the formation of AAA through a complex of sequence of biochemical, cellular and immune events.