预防膀胱肿瘤术后复发的临床研究

目的 探讨不同方法预防膀胱肿瘤术后复发的效果,降低膀胱肿瘤复发率。方法对１９８２～１９９７年间采用膀胱灌注ＢＣＧ、丝裂霉素Ｃ（ＭＭＣ）、噻替呱、口服中药猪苓煎剂、后装腔内放疗５ 不同方法预防膀胱肿瘤复发,评价其效果。结果 随访２～１５年,其复发率分别为ＢＣＧ组３５．１％,猪苓３４．９％,ＭＭＣ组４１．７％,噻替呱组５２．６％,空白对照组６４．７％。后装放疗组处理高危性膀胱癌２５例,随访１２～４２个

Prevention of postoperative recurrence of bladder cancer: a clinical study

Objective To lower postoperative recurrence rate of bladder cancer,the prophylactic effects of five kinds of method on bladder cancer were evaluated. Methods Between 1982 and 1997, 313 patients after TURBT or partial cystectomy were followed up for 2 to 15 years (average 7 6 years). These patients were divided into six groups: BCG,mytomycin C (MMC), thiotepa, Chinese herb medicine Zhuling (Grifola umbellata pilat),afterloading brachytherapy and control group. The prophylactic effects of them on postoperative recurrence of bladder cancer was evaluated. Results During the follow up, the recurrence rates were 35 1% in BCG group,34 9% in Zhuling group, 41 7% in MMC group, 52 6% in thiotepa group, 64 7% in control group,respectively. 25 high risk patients with invading or multiple bladder cancer were treated by afterloading brachytherapy.They were followed up from 12 to 42 months,with a recurrence rate being 24 0%. Conclusions The prophylactic effect of Zhuling and BCG on bladder cancer recurrence was better than MMC. The vale of thiotepa was not significant. The afterloading brachytherapy was of great vale to invading or recurrent, multiple bladder cancer.