直肠癌癌旁移行粘膜MTS1基因产物表达的意义

目的 探讨直肠癌癌旁移行粘膜（ＴＭ）的性质及多种种瘤抑制基因（ＭＴＳ１）基因缺失的临床意义。方法 应用粘液组化方法观察了直肠癌旁ＴＭ的范围,免疫组化方法观察了ＭＴＳ１基因产物表达情况,并与正常粘膜及癌组织进行对照 结果 ＭＴＳ１基因产物在正常直肠膜阳性表达率最高,在癌旁ＴＭ、癌组织表达逐渐减少,三者差异有显著意义（Ｐ〈０．０５）;ＭＴＳ１阴性的直肠癌病例,癌旁ＴＭ的明显高于ＭＴＳ１阳性的病例（Ｐ〉

The expression of MTS1 gene product in transitional mucosa adjacent to rectal carcinomas and its clinical significance

Objective To study the property of transitional mucosa(TM) adjacent to rectal carcinoma and the clinical significance of MTS1 gene deficit. Methods We used the mucinhistochemical methods to observe the range of TM adjacent to rectal carcinoma, and the immunohistochemical method to observe the expression of MTS1 gene product on TM, using normal mucosa and carcinoma tissue as control. Results The positive expression level of MTS1 gene product was the highest in the normal rectal mucosa, gradually defective in TM and carcinoma tissue ( P <0 05). The range of TM with MTS1 negative cases was prominently larger than that with MTS1 positive cases( P <0 05). Conclusions The inactivation of MTS1 gene is relative to the occurrence of rectal carcinoma, suggesting that the TM adjacent to rectal carcinoma possess as certain potential malignancy. TM is related to MTS1 gene expression deficit of rectal carcinoma, showing that MTS1 gene expression deficit or mutation may be a factor inducing transitional change adjacent to carcinoma.